Epigenetic mechanisms in Parkinson's disease.
Identifieur interne : 000031 ( Main/Exploration ); précédent : 000030; suivant : 000032Epigenetic mechanisms in Parkinson's disease.
Auteurs : Ya Feng [République populaire de Chine] ; Joseph Jankovic [États-Unis] ; Yun Wu [République populaire de Chine]Source :
- Journal of the neurological sciences ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Histones, RNA, Untranslated.
- epidemiology : Parkinson Disease.
- genetics : DNA Methylation, Epigenesis, Genetic, Parkinson Disease.
- Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Male, Risk Factors.
Abstract
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.
DOI: 10.1016/j.jns.2014.12.017
PubMed: 25553963
Affiliations:
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Le document en format XML
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Electronic address: yunchw@medmail.com.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080</wicri:regionArea><wicri:noRegion>Shanghai 200080</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25553963</idno><idno type="pmid">25553963</idno><idno type="doi">10.1016/j.jns.2014.12.017</idno><idno type="wicri:Area/PubMed/Corpus">000017</idno><idno type="wicri:Area/PubMed/Curation">000017</idno><idno type="wicri:Area/PubMed/Checkpoint">000014</idno><idno type="wicri:Area/Ncbi/Merge">000483</idno><idno type="wicri:Area/Ncbi/Curation">000483</idno><idno type="wicri:Area/Ncbi/Checkpoint">000483</idno><idno type="wicri:Area/Main/Merge">000031</idno><idno type="wicri:Area/Main/Curation">000031</idno><idno type="wicri:Area/Main/Exploration">000031</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Epigenetic mechanisms in Parkinson's disease.</title><author><name sortKey="Feng, Ya" sort="Feng, Ya" uniqKey="Feng Y" first="Ya" last="Feng">Ya Feng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080</wicri:regionArea><wicri:noRegion>Shanghai 200080</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Wu, Yun Cheng" sort="Wu, Yun Cheng" uniqKey="Wu Y" first="Yun" last="Wu">Yun Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: yunchw@medmail.com.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080</wicri:regionArea><wicri:noRegion>Shanghai 200080</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="e-ISSN">1878-5883</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA Methylation (genetics)</term><term>Epigenesis, Genetic (genetics)</term><term>Female</term><term>Gene-Environment Interaction</term><term>Genetic Predisposition to Disease</term><term>Histones (genetics)</term><term>Humans</term><term>Male</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>RNA, Untranslated (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Histones</term><term>RNA, Untranslated</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>DNA Methylation</term><term>Epigenesis, Genetic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Gene-Environment Interaction</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Feng, Ya" sort="Feng, Ya" uniqKey="Feng Y" first="Ya" last="Feng">Ya Feng</name></noRegion><name sortKey="Wu, Yun Cheng" sort="Wu, Yun Cheng" uniqKey="Wu Y" first="Yun" last="Wu">Yun Wu</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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